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|Nonalcoholic SteatoHepatitis (NASH)
Most NASH pts are obese, middle-aged women with asymptomatic hepatomegaly, diabetes, or hyperlipidmia who do not abuse alcohol. Lab findings typically show that the ALT level is equal to or > the AST level (the reverse in alcoholic hepatitis).
Although some pts develop cirrhosis, portal hypertension, & liver failure, most pts have a good prognosis.. In some cases, the disease can be reversed with weight reduction.
Age: usually between 41-60 years. Predominantly female.
Commonly associated conditions: Obesity, diabetes, hyperlipidemia.
Symptoms: none in 48-100%; vague abdominal discomfort, RUQ abd. pain, fatigue or malaise.
Signs: hepatomegaly, rarely, stigmata of chronic liver disease or portal hypertension.