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MUSCULAR WEAKNESS /PARALYSIS
A. Acute (days) or subacute (weeks) muscular weakness/paralysis
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Alcoholic myopathy
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Botulism
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Acute spinal or peripheral nerve disease
a. Acute idiopathic polyneuritis (Guillain Barre syndrome) or other form
of polyneuropathy (beriberi, porphyria, etc.)
b. Poliomyelitis
c. Rarely polyarteritis nodosa with polyneuropathy
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Organophosphate poisoning
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Polymyositis & dermatomyositis
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Rarely fulminant myasthenia gravis
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Acute paroxysmal myoglobinuria
B. Episodic muscular weakness
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Myasthenia gravis
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Acute thyrotoxic myopathy (also thyrotoxic periodic paralysis)
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Hyperkalemia or hypokalemia
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Symptomatic myasthenia of other types: SLE, RA, polymyositis, nonthymic carcinoma
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Familial periodic paralysis (hypokalemia)
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Hereditary adynamia (hyperkalemic periodic paralysis)
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Paramyotonia congenita (von Eulenburg's disease)
C. Chronic (months to years) muscular weakness/paralysis
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Chronic polymyositis
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Chronic thyrotoxic & other metabolic myopathies
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Progressive muscular dystrophy
a. Duchenne type
b. Facioscapulohumeral type (Landouzy Dejerine)
c. Limb girdle type (Erb's & Leyden Moebius)
d. Distal type (Welander's)
e. Myotonic dystrophy (Steinert's disease)
f. Progressive ophthalmoplegic & oculopharyngeal types
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Chronic neural muscular atrophies
a. Peroneal muscular atrophy (Charcot Marie Tooth)
b. Hypertrophic polyneuritis
c. Amyloid polyneuropathy
d. Chronic nutritional, arsenical, leprous, & other polyneuropathy.
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Slowly progressive or relatively stationary polymyopathies
a. Glycogen storage diseases
b. Congenital benign hypotonia & congenital universal hypoplasia of
muscle
c. Central core disease, rod body (nemaline) & related polymyopathies.
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Progressive muscular atrophies & other motor system disease
a. Amyotrophic lateral sclerosis
b. Progressive bulbar palsy
c. Infantile muscular atrophy
Monday,Sep.21, 1998
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