ch40.01.06 : Conversion of Conventional to SI Units: Therapeutic Drug Monitoring

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	The Medical Algorithms Project

Chapter :

ch40. Unit Conversions

Section :

Unit Conversions

Conversion of Conventional to SI Units: Therapeutic Drug Monitoring

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Overview :

Measurement of drug concentrations performed on serum or plasma can be converted between conventional (US) and SI units if the conversion factors are known.

Specimen: plasma or serum

Generic Drug	Trade Name	Conventional Units	Factor for Conversion	SIU Units
acetaminophen	Tylenol	µg/mL	6.62	µmol/L
amikacin		µg/mL	1.71	µmol/L
amitriptyline		ng/mL	3.61	nmol/L
amobarbital		µg/mL	4.42	µmol/L
amphetamine		µg/mL	7.4	µmol/L
bromide		µg/mL	0.0125	mmol/L
caffeine		µg/mL	5.15	µmol/L
carbamazepine	Tegretol	µg/mL	4.23	µmol/L
carbenicillin		µg/mL	2.64	µmol/L
chloral hydrate		µg/mL	6.69	µmol/L
chloramphenicol		µg/mL	3.09	µmol/L
chlordiazepoxide	Librium	ng/mL	0.00334	µmol/L
chlorpromazine	Thorazine	ng/mL	3.14	nmol/L
chlorpropamide	Diabinese	µg/mL	3.61	µmol/L
cimetidine	Tagamet	µg/mL	3.96	µmol/L
clonazepam	Clonopin	ng/mL	3.17	nmol/L
clonidine	Catapres	ng/mL	4.35	nmol/L
cocaine		ng/mL	3.3	nmol/L
codeine		ng/mL	3.34	nmol/L
desipramine	Norpramin	ng/mL	3.75	nmol/L
diazepam	Valium	ng/mL	0.0035	nmol/L
digitoxin		ng/mL	1.31	nmol/L
digoxin		ng/mL	1.28	nmol/L
disulfiram		µg/mL	3.37	µmol/L
doxepin	Sinequan	ng/mL	3.58	nmol/L
ethanol		mg/dL	0.217	mmol/L
ethchlorvynol	Placidyl	µg/mL	6.92	µmol/L
ethosuximide	Zarontin	µg/mL	7.08	µmol/L
gentamicin		µg/mL	2.09	µmol/L
glutethimide	Doriden	µg/mL	4.6	µmol/L
haloperidol	Haldol	ng/mL	2.66	nmol/L
hydromorphone	Dilaudid	ng/mL	4.85	nmol/L
ibuprofen		µg/mL	4.85	µmol/L
imipramine	Tofranil	ng/mL	3.57	nmol/L
isoniazid		µg/mL	7.29	µmol/L
kanamycin	Kantrex	µg/mL	2.06	µmol/L
lidocaine	Xylocaine	µg/mL	4.27	µmol/L
lithium		mEq/L	1	mmol/L
lorazepam		ng/mL	3.11	nmol/L
LSD		µg/mL	3.09	µmol/L
meperidine	Demerol	ng/mL	4.04	nmol/L
meprobamate		mg/L	4.58	µmol/L
methadone		ng/mL	0.00323	µmol/L
methaqualone	Quaalude	µg/mL	4	µmol/L
methotrexate		ng/mL	2.2	nmol/L
methsuximide		µg/mL	5.29	µmol/L
methyldopa	Aldomet	µg/mL	4.73	µmol/L
morphine		ng/mL	0.0035	µmol/L
nortriptyline		ng/mL	3.8	nmol/L
oxazepam		µg/mL	3.49	µmol/L
oxycodone	Percodan	ng/mL	3.17	nmol/L
paraldehyde		µg/mL	7.57	µmol/L
pentobarbital	Nembutal	µg/mL	4.42	µmol/L
phenacetin		µg/mL	5.58	µmol/L
phenobarbital	Luminal	µg/mL	4.31	µmol/L
phenylbutazone	Butazolidin	µg/mL	3.08	µmol/L
phenytoin	Dilantin	µg/mL	3.96	µmol/L
primidone		µg/mL	4.58	µmol/L
procainamide	Pronestyl	µg/mL	4.23	µmol/L
procaine	Novocaine	µg/mL	4.23	µmol/L
propoxyphene	Darvon	µg/mL	3.07	µmol/L
propranolol		ng/mL	3.86	nmol/L
quinidine		µg/mL	3.08	µmol/L
quinine		µg/mL	3.08	µmol/L
salicylic acid		µg/mL	7.24	µmol/L
secobarbital	Seconal	µg/mL	4.2	µmol/L
theophylline		µg/mL	5.55	µmol/L
tobramycin		µg/mL	2.14	µmol/L
valproic acid		µg/mL	6.93	µmol/L
vancomycin		µg/mL	1	mg/L
warfarin	Coumadin	µg/mL	3.24	µmol/L

References:

American Society of Clinical Pathology. SI Conversion Guide. adapted from AJCP. 1987; 87:140-151.

Conversion Table for SI Units. Transfusion 1990; 30:79-90.

JAMA Instructions for Authors. 1997; 278: 74-76.

Jordan CD, Flood JG, et al. Normal reference laboratory values. NEJM. 1992; 327: 718-724.

Lehmann HP, Henry JB. Appendix 4: SI Units. pages 1449-1462. IN: Henry JB. Clinical Diagnosis and Management by Laboratory Methods, Nineteenth Edition. W.B. Saunders. 1996.

Lundberg GD. SI Unit Implementation - the next step. JAMA. 1988; 260: 73-74.

McQueen MJ. SI Unit Pocket Guide. ASCP Press. Chicago. 1990.

Tietz NW (editor). Clinical Guide to Laboratory Tests, Third Edition. W.B. Saunders Co. 1995.

Wallach J. Interpretation of Laboratory Tests, 6th edition. Little, Brown and Company. 1996. pages 923-936.

Wallach J. Interpretation of Laboratory Tests, 7th edition. Lippincott Williams & Wilkins. 2000. page 978,

Wilson JD, Foster DW. Williams Textbook of Endocrinology, 8th Edition. W.B. Saunders Co. 1992. (front cover interleaf)

Young DS. Implementation of SI Units for Clinical Laboratory Data. Ann Intern Med. 1987; 106:114-129.

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