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Valvular Abnormalities and Cardiovascular Status Following Exposure to Dexfenfluramine or Phentermine/Fenfluramine - Julius M. Gardin , etc. (JAMA. April 5, 2000;283:1703-1709)      Editorials
Prevalence rates and relative risk (RR) of Aortic Regurgitation were significantly increased in anorexigen-treated patients and were 8.9% in the dexfenfluramine group (RR, 2.18), 13.7% in the phentermine/fenfluramine group (RR, 3.34), and 4.1% in the untreated group (P<.001). No statistically significant differences in prevalence were observed for Mital Regurgitaion, thickening or decreased mobility of any valve leaflet, calculated pulmonary artery systolic pressure, or left ventricular ejection fraction. Serious cardiac events (including myocardial infarction, congestive heart failure, or ventricular arrhythmia) occurring at any time were not statistically different in treated and untreated subjects (dexfenfluramine, 9.0%; phentermine/fenfluramine, 4.0%; and untreated, 8.4%);


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