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Lyme disease (Borrelia burgdorferi spirochete)

Clinical Characteristics and Treatment Outcome of Early Lyme Disease in Patients with Microbiologically Confirmed Erythema Migrans - Robert P. Smith, MD, MPH, etc
Ann Intern Med. March 19, 2002;136:421-428 
In major endemic areas in the United States, Lyme disease commonly presents as erythema migrans with homogeneous or central redness and nonspecific flu-like symptoms. Clinical outcome is excellent if antibiotic therapy is administered soon after symptom onset.  

Recognition and Treatment of Erythema Migrans: Are We Off Target?
R.B. Nadelman and G.P. Wormser
Ann Intern Med. March 19, 2002;136:477-479