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Sepsis Syndrome Differential

A.  Infectious

  1. Gram Negative sepsis

  2. Gram Positive Sepsis:  Staphylococcal, Streptococcal,  or Pneumococcal Bacteremia, Toxic Shock Syndrome, Costridial Sepsis

  3. Atypical infection: Chlamydia psittici, Leionella, Typhoidal syndromes

  4. Viral Illness:  Viral hemorrhagic fevers, Hantivirus syndrome

B.  Idiopathic Vasculitides

  1. Polyarteritis Nodosa

  2. Giant Cell Arteritis

  3. ANCA-Related Vasculitides

  4. SLE - Systemic Lupus Erythematosus

  5. Cryoglovulinemia

  6. Serum Sickness

C.  Other Causes

  1. Pre-Eclampsia

  2. Anaphylactic Reactions: Drug reactions, Insect bites, Stevens Johnsons Syndrome (Toxic Epidermal Necrolysis), Certain parasitic infections (as hydatid cyst)

  3. Microangiopathic Hemolytic Anemias (MAHA): Hemolytic Uremic Syndrome (HUS), Thrombotic Thrombocytopenic Purpura (TTP), HELLP Syndrome (severe pre-eclampsia)

  4. Severe Ulcerative Colitis

  5. Cholesterol Emboli Syndrome - eosinophilia may be present

Adrenal Failure (Addisonian Crisis) - eosinophilia may be present

D.  Typical Components of Sepsis Syndrome

  1. Hypotension

  2. Acute Renal Failure

  3. Disseminated Intravascular Coagullopathy (DIC)

  4. Thermal Dysregulation (hypothermia and/or fever)

  5. Pulmonary Edema

REF: Outlines of Clinical Medicine 2004