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Antibiotics Drugs - Introduction
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|INTRODUCTION TO THE ANTIBACTERIAL AGENTS
The Mechanisms of Actions of the antibacterial agents:
2. Inhibition of bacterial ribosome protein synthesis:
3. Inhibition of bacterial folic acid metabolsim:
4. Inhibition of bacterial nucleic acid synthesis or activity:
5. Alteration of bacterial cell membrane permeability
The Susceptibility Testing of antimicrobial agents:
2. The quantitative assessment
The bacteria are usually considered to be susceptible to a drug if the achievable peak serum concentration exceeds the MIC by at least 4x.
The break point of an antibiotics is the concentration of the antibiotics that separates susceptible from resistant bacteria.
When a majority of the isolates of a given bacterial species are inhibited at concentrations below the breakpoint, the species is within the spectrum of the drug.
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